Wortmannin potentiates roscovitine-induced growth inhibition in human solid tumor cells by repressing PI3K/Akt pathway.

@article{Zhang2009WortmanninPR,
  title={Wortmannin potentiates roscovitine-induced growth inhibition in human solid tumor cells by repressing PI3K/Akt pathway.},
  author={Feng Zhang and Tao Zhang and Tao Jiang and Rong Zhang and Zeng-hui Teng and Chen Li and Zhong-ping Gu and Qi-bing Mei},
  journal={Cancer letters},
  year={2009},
  volume={286 2},
  pages={
          232-9
        }
}
Roscovitine has been reported to have anti-tumor effects in some cancer cell lines. The phosphatidylinositol-3-kinase (PI3K) signaling, which activates protein kinase B (PKB)/Akt, is known to mediate cell survival. The current study examined the role of wortmannin, a PI3K inhibitor, as a chemosensitizer for roscovitine and its proposed mechanism of action. The results showed that wortmannin significantly chemosensitized three human tumor cell lines (A549, HCT116 and HeLa cells). In A549 cells… CONTINUE READING
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