Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas

@article{Fujita1998WortmanninEA,
  title={Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas},
  author={Eriko Fujita and Yoriko Kouroku and Yasuko Miho and Toshifumi Tsukahara and S. Ishiura and Takashi Momoi},
  journal={Cell Death & Differentiation},
  year={1998},
  volume={5},
  pages={289-297}
}
CPP32/apopain (Caspase-3), a protease of the Ced-3/ICE family, is a central mediator in the apoptosis induced by TNF or anti-Fas. In this study we demonstrate that wortmannin, an inhibitor of PI-3K, enhances the activation of CPP32 (Caspase-3) and DNA fragmentation in TNF-treated U937 cells and anti-Fas-treated Jurkat cells. Caspase-3-like activity, Ac-DEVD-MCA cleavage activity, is enhanced by wortmannin in the range of the concentration (1–100 nM) specifically inhibiting PI-3K. LY294002… CONTINUE READING

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