Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma.

@article{Brunello2009WorseningOO,
  title={Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma.},
  author={Antonella Brunello and Giorgia Saia and Alberto Bedogni and Daniela Scaglione and Umberto Basso},
  journal={Bone},
  year={2009},
  volume={44 1},
  pages={173-5}
}
We report on the potential association of suspected bisphosphonate-associated osteonecrosis of the jaw (BRONJ) recurrence with the use of the novel antiangiogenic drug sunitinib. A 59 year-old patient affected by metastatic renal cell carcinoma (RCC) and established BRONJ experienced consecutive episodes of painful jaw infection with cutaneous fistula and bone sequestration which occurred during active treatment with sunitinib, improved after discontinuation and antibiotic therapy, then rapidly… CONTINUE READING

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