Worms and allergy

  title={Worms and allergy},
  author={E. M. Carvalho and Luciana S. Bastos and Maria Ilma Araújo},
  journal={Parasite Immunology},
Worms and asthma are associated with a type 2 immune response, but evidence has accumulated that helminth infection is negatively associated with atopy, prevalence of allergic diseases and severity of asthma. One important difference between these polarized type 2 responses is that in allergy modulation of the immunological response is not appropriate, whereas in infection with helminths, several host mechanisms down‐regulate the host immune response. As a result, patients infected with worms… 

Atopic disorders and parasitic infections.

Regulation of type 1 diabetes, tuberculosis, and asthma by parasites

Investigating possible mechanisms through which helminthic parasites modulate host immunity could lead to treatment strategies that specifically modulate the immune response as well as address fundamental questions in immunobiology.

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

This review discusses A. simplex pathogenesis in humans, covering immune hypersensitivity reactions both in the context of a living infection and in terms of exposure to its allergens by other routes.

Ascaris and Allergy

Helminth-induced IgE and protection against allergic disorders.

How helminth infection can lead to IgE cross-reactivity with allergens and how this IgE has poor biological activity is discussed is important for developing new diagnostic methods and treatments for allergic disorders in low-to-middle-income countries.

Parasitic nematode modulation of allergic disease

The evidence strongly favors a protective role for nematodes; thus, the search is on to find the molecules involved, with a view toward using them for therapeutic purposes.

Mycobacterium-Induced Th1, Helminths-Induced Th2 Cells and the Potential Vaccine Candidates for Allergic Asthma: Imitation of Natural Infection

It is demonstrated that natural infection with Mycobacterium tuberculosis (Mtb) prevents the development of allergic asthma, thus Bacille Calmette-Guérin (BCG) vaccine is suggested at early age to mediate the same prevention particularly with increasing its efficiency through genetic engineering-based modifications.

Therapeutic immunomodulators from nematode parasites

The evidence supporting the idea that helminths of the phylum Nematoda (nematodes) may protect against the development of autoimmunity and allergy is reviewed.

Immunologic responses to common antigens in helminthic infections and allergic disease

  • L. ArrudaA. Santos
  • Biology, Medicine
    Current opinion in allergy and clinical immunology
  • 2005
Purpose of reviewIt is estimated that over 1 billion individuals are infected with helminth parasites worldwide. Epidemiologic studies have pointed to a protective role of helminthic infections in

Allergy, parasites, and the hygiene hypothesis.

The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders.

Can intestinal helminth infections (geohelminths) affect the development and expression of asthma and allergic disease?

  • P. Cooper
  • Biology, Medicine
    Clinical and experimental immunology
  • 2002
Evidence is provided that the expression of allergic inflammation in different regions of the Tropics may depend partly on local differences in the endemicity of geohelminth infections.

Helminth infection modulates the development of allergen-induced airway inflammation.

Results show that infection with Nippostrongylus brasiliensis suppresses the development of allergen-induced airway eosinophilia and that this effect may be mediated by IL-10, and support the view that helminth infections can contribute to the suppression of allergies in humans.

Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma.

Dermatophagoides pteronyssinus-specific immune responses in patients with asthma are evaluated by measuring levels of T helper 2 (Th2) cytokines in peripheral blood mononuclear cell (PBMC) cultures.

Infection with Strongyloides venezuelensis Induces Transient Airway Eosinophilic Inflammation, an Increase in Immunoglobulin E, and Hyperresponsiveness in Rats

The results show that the migration of S. venezuelensis larvae through the lungs of infected rats induces a local eosinophilic inflammation process which is mostly focal and parenchymal for rats infected a single time and which is peribronchial after multiple infections.

Exploiting worm and allergy models to understand Th2 cytokine biology

Many findings from the schistosomiasis model have been subsequently demonstrated in models of allergic disease, illustrating the utility of this model to dissect basic mechanisms of Th2-mediated inflammation.

Parasites and the hygiene hypothesis

Recent findings and new concepts relating to the associations between parasites and allergies at the epidemiological, cellular and molecular level are discussed.