WormBase 2014: new views of curated biology

Abstract

WormBase (http://www.wormbase.org/) is a highly curated resource dedicated to supporting research using the model organism Caenorhabditis elegans. With an electronic history predating the World Wide Web, WormBase contains information ranging from the sequence and phenotype of individual alleles to genome-wide studies generated using next-generation sequencing technologies. In recent years, we have expanded the contents to include data on additional nematodes of agricultural and medical significance, bringing the knowledge of C. elegans to bear on these systems and providing support for underserved research communities. Manual curation of the primary literature remains a central focus of the WormBase project, providing users with reliable, up-to-date and highly cross-linked information. In this update, we describe efforts to organize the original atomized and highly contextualized curated data into integrated syntheses of discrete biological topics. Next, we discuss our experiences coping with the vast increase in available genome sequences made possible through next-generation sequencing platforms. Finally, we describe some of the features and tools of the new WormBase Web site that help users better find and explore data of interest.

DOI: 10.1093/nar/gkt1063

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@inproceedings{Harris2014WormBase2N, title={WormBase 2014: new views of curated biology}, author={Todd W. Harris and Joachim Baran and Tamberlyn Bieri and Abigail Cabunoc and Juancarlos Chan and Wen J. Chen and Paul Davis and James Done and Christian Grove and Kevin L. Howe and Ranjana Kishore and Raymond Lee and Yuling Li and Hans-Michael M{\"{u}ller and Cecilia Nakamura and Philip Ozersky and Michael Paulini and Daniela Raciti and Gary Schindelman and Mary Ann Tuli and Kimberly Van Auken and Daniel Wang and Xiaodong Wang and Gary M Williams and J. D. Wong and Karen Yook and Tim Schedl and Jonathan Hodgkin and Matthew Berriman and Paul J. Kersey and John Spieth and Lincoln Stein and Paul W. Sternberg}, booktitle={Nucleic Acids Research}, year={2014} }