Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci

@article{Kim2005WorldwideHD,
  title={Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci},
  author={Unkyung Kim and Stephen Wooding and Dante Ricci and Lynn B. Jorde and Dennis Drayna},
  journal={Human Mutation},
  year={2005},
  volume={26}
}
Bitter taste perception in humans is mediated by receptors encoded by 25 genes that together comprise the TAS2R (or T2R) gene family. The ability to identify the ligand(s) for each of these receptors is dependent on understanding allelic variation in TAS2R genes, which may have a significant effect on ligand recognition. To investigate the extent of coding variation among TAS2R alleles, we performed a comprehensive evaluation of sequence and haplotype variation in the human bitter taste… Expand
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Signatures of Natural Selection in a Primate Bitter Taste Receptor
  • S. Wooding
  • Biology, Medicine
  • Journal of Molecular Evolution
  • 2011
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References

SHOWING 1-10 OF 33 REFERENCES
Adaptive diversification of bitter taste receptor genes in Mammalian evolution.
TLDR
A phylogenetic analysis of the T2R genes suggests that they can be classified into three main groups, which are designated A, B, and C, and reveals that phylogenetically closely related T1R genes are close in their chromosomal locations, demonstrating tandem gene duplication as the primary source of new T2Rs. Expand
Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide
TLDR
A small region on chromosome 7q that shows strong linkage disequilibrium between single-nucleotide polymorphism (SNP) markers and PTC taste sensitivity in unrelated subjects and a single gene that encodes a member of the TAS2R bitter taste receptor family is identified. Expand
Natural selection and molecular evolution in PTC, a bitter-taste receptor gene.
The ability to taste phenylthiocarbamide (PTC) is a classic phenotype that has long been known to vary in human populations. This phenotype is of genetic, epidemiologic, and evolutionary interestExpand
Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes.
TLDR
Examining the intra-specific variations of all 25 genes of the human TAS2R repertoire suggests surprisingly reduced sensory capabilities of humans in comparison with many other mammals. Expand
Population differences in haplotype structure within a human olfactory receptor gene cluster.
TLDR
The data suggests that OR genes may have evolved to create different functional repertoires in distinct human populations, including Pygmies, Bedouins, Yemenite Jews and Ashkenazi Jews. Expand
Population differences in the human functional olfactory repertoire.
TLDR
Interestingly, when analyzing the entire OR coding regions, the authors find an excess of high-frequency derived alleles at many loci in the Caucasian sample but less so in the Pygmy sample, suggesting that African populations may have a larger repertoire of functional OR genes. Expand
DNA variability of human genes
TLDR
A deeper understanding of how SNPs are distributed within human genes and the patterns of linkage disequilibrium among SNPs will be of vital importance when trying to identify the genetic contribution to complex phenotypes such as aging. Expand
The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides
TLDR
It is reported that a human member of this family, TAS2R16, is present in taste receptor cells on the tongue and is activated by bitter β-glucopyranosides, which links the recognition of a specific chemical structure to the perception of bitter taste. Expand
Genetics of Human Taste Perception
TLDR
Sweet and umami tastes, mediated by TAS1R receptors, are becoming well-characterized at the molecular genetic level, and these taste classes are now targets for linkage, positional cloning, and genetic association strategies. Expand
Evidence for positive selection and population structure at the human MAO-A gene
TLDR
The analysis of human nucleotide diversity at a genetic locus known to be involved in a behavioral phenotype, the monoamine oxidase A gene, finds both a reduction in levels of diversity and an excess of high frequency-derived variants, as expected after a recent episode of positive selection. Expand
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