Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review.

@article{Guedes2010WorldwideFO,
  title={Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review.},
  author={Leonor Correia Guedes and Joaquim J. Ferreira and M{\'a}rio Miguel Rosa and Miguel Coelho and Vincenzo Bonifati and Cristina Sampaio},
  journal={Parkinsonism & related disorders},
  year={2010},
  volume={16 4},
  pages={
          237-42
        }
}
BACKGROUND The LRRK2 G2019S mutation is the most frequent known cause of familial and sporadic Parkinson's disease. Knowledge of its worldwide frequency distribution is essential for clinical and molecular research as well as genetic counseling. OBJECTIVES To conduct a systematic review of the reported frequency of G2019S in different populations and to assess critically the quality of the clinical studies. METHODS We conducted a systematic review of all published papers on G2019S frequency… CONTINUE READING
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