Worldwide Trends in the Use of Animals in Research: The Contribution of Genetically-modified Animal Models

@article{Ormandy2009WorldwideTI,
  title={Worldwide Trends in the Use of Animals in Research: The Contribution of Genetically-modified Animal Models},
  author={E. Ormandy and C. Schuppli and D. Weary},
  journal={Alternatives to Laboratory Animals},
  year={2009},
  volume={37},
  pages={63 - 68}
}
The Three Rs — Reduction, Replacement and Refinement — which were first proposed in 1959 by Russell and Burch, have become widely accepted principles in the governance of humane animal research. However, there is substantial variation in the ways in which different countries document the numbers and types of research animals used, making it difficult to determine how effectively the Three Rs are being implemented. Here, we provide the first data illustrating worldwide trends in animal use for… Expand

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