Worldwide Genetic Features of HIV-1 Env α4β7 Binding Motif: The Local Dissemination Impact of the LDI Tripeptide.

Abstract

BACKGROUND HIV-1 gp120 binds to integrin α4β7, a homing receptor of lymphocytes to gut-associated lymphoid tissues. This interaction is mediated by the LDI/V tripeptide encoded in the V2-loop. This tripeptide mimics similar motifs in mucosal addressin cellular adhesion molecule (MAdCAM) and vascular CAM (VCAM), the natural ligands of α4β7. In this study, we… (More)
DOI: 10.1097/QAI.0000000000000802

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@article{Hait2015WorldwideGF, title={Worldwide Genetic Features of HIV-1 Env α4β7 Binding Motif: The Local Dissemination Impact of the LDI Tripeptide.}, author={Sabrina H. Hait and Esmeralda A.J.M. Soares and Eduardo Sprinz and James A. Arthos and Elizabeth Stankiewicz Machado and Marcelo A Soares}, journal={Journal of acquired immune deficiency syndromes}, year={2015}, volume={70 5}, pages={463-71} }