World workshop on oral medicine VII: Direct anticoagulant agents management for invasive oral procedures: A systematic review and meta-analysis.

  title={World workshop on oral medicine VII: Direct anticoagulant agents management for invasive oral procedures: A systematic review and meta-analysis.},
  author={Maddalena Manfredi and Bella Dave and Daniela Percudani and Janina Christoforou and Jumana Karasneh and Pedro Diz Dios and Michael Glick and Navdeep Kumar and Peter B. Lockhart and Lauren L. Patton},
  journal={Oral diseases},
  volume={25 Suppl 1},
OBJECTIVES This systematic review aimed to evaluate the current literature regarding the importance of discontinuing or not discontinuing direct oral anticoagulants (DOACs) before invasive oral procedures, and to establish the frequency and type of postoperative bleeding events in patients. MATERIAL AND METHODS We searched PubMed, Embase, Scopus, Web of Science, and the Cochrane Library up until November 5, 2018. Selection of the studies, extraction of data, qualitative, and bias assessment… 

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Among patients undergoing low-to-moderate risk dental procedures while receiving direct-acting oral anticoagulant (DOAC) therapy, bleeding rates were low regardless of whether the DOAC was held or continued surrounding the procedure.

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Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study

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Post-operative Bleeding Risk in Dental Surgery for Patients on Oral Anticoagulant Therapy: A Meta-analysis of Observational Studies

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Dental treatment may be safely delivered following continuation, partial interruption, or complete interruption of the DOAC dose for dental treatment, according to the experience of patients on DOACs.

Bleeding related to dental treatment in patients taking novel oral anticoagulants (NOACs): a retrospective study

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Should we fear direct oral anticoagulants more than vitamin K antagonists in simple single tooth extraction? A prospective comparative study

DOAC and VKA patients showed the same incidence of bleeding complications after simple single tooth extraction, and non-ceasing of DOAC therapy seems to be appropriate for simple single dental extractions.

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This review focuses on 4 novel Direct Oral Anticoagulants (DOACs) and proposes a matrix for the general dentists to assess bleeding risk in dental management of patient on DOACs, which covers the pharmacology of DOacs, bleeding complications, risk associated with discontinuation, monitoring/reversal, and implications for the dental practitioners.