Working principles in the immune system implied by the "peptidic self" model.

  title={Working principles in the immune system implied by the "peptidic self" model.},
  author={P. Kourilsky and G{\'e}rard Chaouat and Chantal Rabourdin-Combe and Jean Michel Claverie},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={84 10},
The hypothesis that self as well as foreign proteins are processed into peptides and presented by major histocompatibility complex antigens leads to a set of working principles that could govern cellular interactions in immune responses. In particular, "idiopeptides," derived from immunoglobulins and T-cell receptors and recognized by appropriate T cells, are expected to play an important regulatory role. We show here that these speculations fit into a consistent view of the immune system. 
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