Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex.

@article{Cottrell2013WorkingMI,
  title={Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex.},
  author={Jeffrey Richard Cottrell and Jonathan M. Levenson and Sung Hyun Kim and Helen E. Gibson and Kristen A. Richardson and Michael Sivula and Bing Nan Li and Crystle J. Ashford and Karen A Heindl and Ryan J Babcock and David Rose and Chris Martin Hempel and Kjesten A. Wiig and Pascal Laeng and Margaret E. Levin and Timothy A Ryan and David Jason Gerber},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 27},
  pages={
          10938-49
        }
}
Working memory is an essential component of higher cognitive function, and its impairment is a core symptom of multiple CNS disorders, including schizophrenia. Neuronal mechanisms supporting working memory under normal conditions have been described and include persistent, high-frequency activity of prefrontal cortical neurons. However, little is known about the molecular and cellular basis of working memory dysfunction in the context of neuropsychiatric disorders. To elucidate synaptic and… CONTINUE READING
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