Working-memory endophenotype and dyslexia-associated genetic variant predict dyslexia phenotype

@article{Mnnel2015WorkingmemoryEA,
  title={Working-memory endophenotype and dyslexia-associated genetic variant predict dyslexia phenotype},
  author={Claudia M{\"a}nnel and Lars Meyer and Arndt Wilcke and Johannes Boltze and Angela D. Friederici},
  journal={Cortex},
  year={2015},
  volume={71},
  pages={291-305}
}
Developmental dyslexia, a severe impairment of literacy acquisition, is known to have a neurological basis and a strong genetic background. However, effects of individual genetic variations on dyslexia-associated deficits are only moderate and call for the assessment of the genotype's impact on mediating neuro-endophenotypes by the imaging genetics approach. Using voxel-based morphometry (VBM) in German participants with and without dyslexia, we investigated gray matter changes and their… CONTINUE READING

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