Working memory and the homeostatic control of brain adenosine by adenosine kinase.

@article{Singer2012WorkingMA,
  title={Working memory and the homeostatic control of brain adenosine by adenosine kinase.},
  author={Philipp Singer and Stephanie McGarrity and H-y Shen and Detlev Boison and Benjamin K. Yee},
  journal={Neuroscience},
  year={2012},
  volume={213},
  pages={81-92}
}
The neuromodulator adenosine maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors (ARs) in a brain region-specific manner. AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effects on learning and memory in normal animals are equivocal. An alternative approach to reduce AR activation is to lower the extracellular tone of adenosine, which can be achieved by… CONTINUE READING