Woodchuck hepatitis and hepatocellular carcinoma: correlation of histologic with virologic observations.

@article{Popper1981WoodchuckHA,
  title={Woodchuck hepatitis and hepatocellular carcinoma: correlation of histologic with virologic observations.},
  author={Hans Popper and James Wai-Kuo Shih and John L. Gerin and Doris C Wong and B H Hoyer and William T London and D. Lewis Sly and Robert H. Purcell},
  journal={Hepatology},
  year={1981},
  volume={1 2},
  pages={91-8}
}
The livers of 33 captive woodchucks were examined histologically in 30 biopsy and 10 autopsy specimens and the findings were correlated with serum determinations for woodchuck hepatitis virus (WHV), surface antigen (WHsAg) and antibody (anti-WHs), and WHV DNA and DNA polymerase. The liver appeared normal in all 3 serum-negative animals, 7 of 16 with indeterminate WHV status, and 1 of 4 with anti-WHs, but not in 10 animals with WHsAg, WHV DNA, and DNA polymerase. Mild hepatic inflammation was… CONTINUE READING

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