Women with insufficient 25-hydroxyvitamin D without secondary hyperparathyroidism have altered bone turnover and greater incidence of vertebral fractures.

@article{Ikegami2011WomenWI,
  title={Women with insufficient 25-hydroxyvitamin D without secondary hyperparathyroidism have altered bone turnover and greater incidence of vertebral fractures.},
  author={Shota Ikegami and Mikio Kamimura and Shigeharu Uchiyama and H. Ogata H. Kato},
  journal={Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association},
  year={2011},
  volume={16 5},
  pages={
          573-80
        }
}
BACKGROUND The connection of 25-hydroxyvitamin D [25(OH)D] with bone metabolism is reported to occur indirectly through parathyroid hormone (PTH) activity. However, we hypothesized that 25(OH)D insufficiency raises the risk of bone fracture independent of PTH, since 25(OH)D insufficiency is not always accompanied by hyperparathyroidism. The aim of this study was to show a direct association between 25(OH)D, bone turnover markers, and fractures that was independent of PTH. METHODS We measured… CONTINUE READING

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