Corpus ID: 22870794

Women relatives of Hispanic patients with type 2 diabetes are more prone to exhibit metabolic disturbances.

@article{Florez1999WomenRO,
  title={Women relatives of Hispanic patients with type 2 diabetes are more prone to exhibit metabolic disturbances.},
  author={Hermes Jose Florez and Elena Ryder and Gilberto Campos and Virginia Fern{\'a}ndez and Luz Marina Morales and Humberto Alejandro Rosales Valbuena and E Rinc{\'o}n and M E G{\'o}mez and Xiomara Raleigh},
  journal={Investigacion clinica},
  year={1999},
  volume={40 2},
  pages={
          127-42
        }
}
Hyperinsulinemia and impaired insulin action are familial and predictive of Type 2 diabetes onset. Since high levels of insulin are characteristic of our general (venezuelan)hispanic population, the purpose of this investigation was to identify early metabolic defects in a group of healthy first degree relatives of Type 2 diabetic patients. We studied 46 (29 women and 17 men; ages ranging 18-66 y) first degree relatives of Type 2 diabetic patients comparing them with 22 (12 women and 10 men… Expand
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References

SHOWING 1-10 OF 18 REFERENCES
Features of Syndrome X in First-Degree Relatives of NIDDM Patients
TLDR
Feature of syndrome X occur more frequently in relatives of NIDDM patients than in control subjects with no family history of diabetes, and insulin resistance and HDL cholesterol concentrations were independent of obesity. Expand
Increased insulin concentrations in nondiabetic offspring of diabetic parents.
TLDR
A stepwise increase in fasting insulin levels in nondiabetics with neither, one, or both parents with diabetes is found, and differences in insulin sums according to family history remained statistically significant in analyses of covariance. Expand
Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with noninsulin-dependent diabetes mellitus.
TLDR
The results demonstrated that the ability of insulin to stimulate disposal of a glucose load was significantly reduced in the subjects with a positive family history of noninsulin-dependent diabetes. Expand
Metabolic abnormalities in children of non-insulin dependent diabetics.
TLDR
Results indicate that young offspring of selected non-insulin dependent diabetics can show extensive metabolic changes including impaired glucose tolerance, associated with hyperinsulinaemia and hyperglucagonaemia. Expand
Metabolic profile and insulin sensitivity in healthy young Mexicans with a strong family history of non-insulin-dependent diabetes mellitus in the paternal branch.
TLDR
Healthy young Mexicans with a strong family history of NIDDM in the paternal branch were not different in insulin sensitivity from those without family history, and only showed a slight increase in serum total cholesterol. Expand
Hyperinsulinemia as a possible etiology for the high prevalence of non insulin dependent diabetes in Mexican Americans.
TLDR
The data indicate that, like other populations at high risk for NIDDM, Mexican Americans have more hyperinsulinemia than can be accounted for by their adiposity and body fat distribution. Expand
Hyperinsulinemia Is Associated With the Incidence of Hypertension and Dyslipidemia in Middle-Aged Men
TLDR
The role of hyperinsulinemia in incident hypertension and Dyslipidemia is demonstrated and it is suggested that both hypertension and dys Lipidemia are associated with insulin metabolism disturbance, independently of obesity and body weight. Expand
Prospective Analysis of The Insulin-Resistance Syndrome (Syndrome X)
TLDR
The results support the existence of a metabolic syndrome and the relationship of that syndrome to multiple metabolic disorders by showing that elevations of insulin concentration precede the development of numerous metabolic disorders. Expand
Insulin Sensitivity, Glucose Effectiveness, and Body Fat Distribution Pattern in Nondiabetic Offspring of Patients With NIDDM
TLDR
It is confirmed that insulin insensitivity but not a reduced glucose effectiveness exists in young glucose-tolerant offspring of patients with NIDDM and the reduced SI appears to be causally related to the total body fat content and may be a familial and/or genetic trait in the offspring. Expand
Racial differences in the relation between blood pressure and insulin resistance.
TLDR
The relations between insulinemia, insulin resistance, and blood pressure differ among racial groups and may be mediated by mechanisms active in whites, but not in Pima Indians or blacks. Expand
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