Wolf-Hirschhorn syndrome and a split-hand malformation.

  title={Wolf-Hirschhorn syndrome and a split-hand malformation.},
  author={Michael J Bamshad and Jack O'Quinn and John C Carey},
  journal={American journal of medical genetics},
  volume={75 4},
Ectrodactyly has not previously been reported in children with Wolf-Hirschhorn syndrome (WHS). Based on this premise and the identification of an unbalanced translocation between chromosomes 4p15 and 10q25 in a fetus with ectrodactyly and hemimelia, a second locus for dominantly inherited split hand/foot malformation (SHFM3) was mapped to chromosome 10q24-q25. We present the clinical findings of an infant with WHS and SHFM and suggest that the presence of additional loci on 4p which modify… CONTINUE READING