Wolbachia in the inflammatory pathogenesis of human filariasis.

  title={Wolbachia in the inflammatory pathogenesis of human filariasis.},
  author={Mark J Taylor},
  journal={Annals of the New York Academy of Sciences},
  • Mark J Taylor
  • Published 2003 in Annals of the New York Academy of Sciences
Filarial nematodes cause some of the most debilitating diseases in tropical medicine. Recent studies, however, have implicated the parasites' endosymbiotic Wolbachia bacteria, rather than the nematode, as the cause of inflammatory-mediated filarial disease. Soluble extracts of a variety of filarial species stimulate innate inflammatory responses, which are absent or reduced when using extracts derived from species either devoid of bacteria, or those cleared of bacteria by antibiotics… CONTINUE READING
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