Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

@inproceedings{Hoerauf2007WolbachiaED,
  title={Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study},
  author={Achim Hoerauf and Sabine Specht and Marcelle Buettner and Kenneth M Pfarr and Sabine Mand and Rolf Fimmers and Yeboah Marfo-Debrekyei and Peter Konadu and Alexander Yaw Debrah and Claudio Bandi and Norbert W Brattig and Anna Albers and John Aseidu Larbi and Linda Batsa and Mark J Taylor and Ohene Adjei and Dietrich W. B{\"u}ttner},
  booktitle={Medical Microbiology and Immunology},
  year={2007}
}
In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4–6 weeks, followed by ivermectin (IVM) after 6 months. After 6–27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxycycline resulted in endobacteria depletion and female worm sterilization. The 6-week treatment was macrofilaricidal, with >60% of the female worms found dead, despite the presence of new, Wolbachia… CONTINUE READING

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Wolbachia Endosymbionts: an achilles’ heel of Wlarial nematodes

  • A Hoerauf, K Pfarr
  • 2007
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