Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL‐6/STAT3 signaling pathway

@article{Zhao2015WogoninSH,
  title={Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL‐6/STAT3 signaling pathway},
  author={Yue Zhao and Jingyue Yao and Xiao-ping Wu and Li Zhao and Yuxin Zhou and Yi Zhang and Qidong You and Qinglong Guo and Na Lu},
  journal={Molecular Carcinogenesis},
  year={2015},
  volume={54}
}
Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment facilitates tumor metastasis. Clinically, it will be a promising choice to suppress tumor metastasis by targeting inflammatory microenvironment. Our previous studies have demonstrated that wogonin (a bioflavonoid isolated from the traditional Chinese medicine of Huang‐Qin) possesses the anti‐metastatic and anti‐inflammatory activity, but we have little idea about its… 
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TLDR
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wogonin, a compound extracted from herbs, to mediate inflam- matory reactions in vascular inflammation. Wogonin was loaded in a well‐characterized polymeric biomaterial carrier. In mice with streptozotocin‐induced vascular inflammation, wogonin treatment regulated the production of inflammatory cyto
TLDR
In mice with streptozotocin‐induced vascular inflammation, wogonin treatment regulated the production of inflammatory cytokines, including interleukin‐6, tumor necrosis factor‐α and granulocyte macrophage colony‐stimulating factor.
Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway
TLDR
It is demonstrated that wogonin could induce apoptosis and reverse sunitinib resistance of R CC cells via inhibiting CDK4-RB pathway, thus suggesting a potential therapeutic implication in the future management of RCC patients.
Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling
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It is revealed that ART, DHA, and ARTS could suppress lung-tumor progression by inhibiting Wnt/β-catenin pathway, thereby suggesting a novel target for ART, H2O, and DHA in cancer treatment.
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References

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Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia
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  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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