Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages.

@article{Chen2011WogoninPC,
  title={Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages.},
  author={Chien-Yu Chen and Song-Kun Shyue and Li-Chieh Ching and Kuo-Hui Su and Y Wu and Yu Ru Kou and A H Chiang and Ching-Chian Pan and Tzong-Shyuan Lee},
  journal={The Journal of nutritional biochemistry},
  year={2011},
  volume={22 11},
  pages={1015-21}
}
Wogonin, one component in Scutellaria baicalensis Georgi extracts, has several beneficial properties for cancers and inflammatory diseases. However, the efficacy of wogonin in cholesterol metabolism of macrophages remains unknown. In macrophages, cholesterol uptake is controlled by scavenger receptors (SR-A and CD36) and cholesterol efflux by SR-BI, ATP-binding cassette transporter-A1 (ABCA1) and ABCG1. In the present study, we investigated the effect and underlying molecular mechanism of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…