Wogonin inhibits inducible prostaglandin E(2) production in macrophages.

@article{Wakabayashi2000WogoninII,
  title={Wogonin inhibits inducible prostaglandin E(2) production in macrophages.},
  author={Ichiro Wakabayashi and Kiyoshi Yasui},
  journal={European journal of pharmacology},
  year={2000},
  volume={406 3},
  pages={477-81}
}
Effects of 5,7-dihydroxy-8-methoxyflavone (wogonin) on cyclooxygenase-2 (COX-2)-mediated prostaglandin E(2) production in macrophages were investigated. Stimulation with lipopolysaccharide (LPS; 1 microg/ml) greatly increased prostaglandin E(2) production in RAW 264.7 murine macrophages. The stimulated prostaglandin E(2) production was abolished in the presence of indomethacin (1 microM) or cycloheximide (2 microM), suggesting that the increased production of prostaglandin E(2) by LPS reflects… CONTINUE READING