Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax.

@article{Zhang2013WogoninIA,
  title={Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax.},
  author={Meng Zhang and Li Liu and Yuling Chen and Xiao-ying Tian and Jian Qin and Dongmei Wang and Zhi Wu Li and Sui-Lin Mo},
  journal={Life sciences},
  year={2013},
  volume={92 1},
  pages={55-62}
}
AIMS Wogonin is one of the major constituents derived from Scutellaria Baicalensis, which has been reported to inhibit cell growth and/or induce apoptosis in various cancer cell lines. We aim to investigate the anticancer effects and associated mechanisms of wogonin on human multiple myeloma cell line in vitro. MAIN METHODS Effects of wogonin on the proliferation, cell cycle progression, and apoptosis of human myeloma cells were examined in vitro. The proteins associated with the biological… CONTINUE READING
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