Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1

@inproceedings{Polier2011WogoninAR,
  title={Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1},
  author={Gernot Polier and Jiongyan Ding and Badireenath Konkimalla and Dirk Eick and Nigel Ribeiro and Ronald Koehler and Marco Giaisi and Thomas Efferth and Laurent D{\'e}saubry and Peter Heinrich Krammer and Min Li-Weber},
  booktitle={Cell Death and Disease},
  year={2011}
}
The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin has been shown to induce apoptosis in different cancer cells and to suppress growth of human cancer xenografts in vivo. However, its direct targets remain unknown. In this study, we demonstrate for the first time that wogonin and structurally related natural flavones, for example, apigenin, chrysin and luteolin, are inhibitors of cyclin-dependent… CONTINUE READING