Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11.

@article{Kaupmann1992WobblerAM,
  title={Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11.},
  author={Klemens Kaupmann and Dominique Simon-Chazottes and Jean Louis Gu{\'e}net and Harald Jockusch},
  journal={Genomics},
  year={1992},
  volume={13 1},
  pages={
          39-43
        }
}
The wobbler mouse (genotype wr/wr) has been considered as an animal model for human neurodegenerative disorders. In the homozygous condition, the autosomal mutation wobbler (wr) causes a motoneuron disease and gonadal dysfunction. We have genetically mapped the wr gene, using an interspecific backcross between the laboratory strain C57BL/6J (wr/+) and Mus spretus. The expected percentage of wobbler progeny were obtained, but heterogeneous expression of the wobbler phenotype indicated the… CONTINUE READING
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