Wobble base-pairing slows in vivo translation elongation in metazoans.

  title={Wobble base-pairing slows in vivo translation elongation in metazoans.},
  author={Michael Stadler and A. Fire},
  volume={17 12},
In the universal genetic code, most amino acids can be encoded by multiple trinucleotide codons, and the choice among available codons can influence position-specific translation elongation rates. By using sequence-based ribosome profiling, we obtained transcriptome-wide profiles of in vivo ribosome occupancy as a function of codon identity in Caenorhabditis elegans and human cells. Particularly striking in these profiles was a universal trend of higher ribosome occupancy for codons translated… CONTINUE READING
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