Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.

@article{Tan2014WntsPB,
  title={Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.},
  author={Si Tan and Kshemendra Senarath-Yapa and Michael Thomas Chung and Michael Thornton Longaker and Joy Y Wu and Roeland Nusse},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 49},
  pages={E5262-71}
}
Wnt signaling is a critical regulator of bone development, but the identity and role of the Wnt-producing cells are still unclear. We addressed these questions through in situ hybridization, lineage tracing, and genetic experiments. First, we surveyed the expression of all 19 Wnt genes and Wnt target gene Axin2 in the neonatal mouse bone by in situ hybridization, and demonstrated--to our knowledge for the first time--that Osterix-expressing cells coexpress Wnt and Axin2. To track the behavior… CONTINUE READING
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