Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

  title={Wnts in adult brain: from synaptic plasticity to cognitive deficiencies},
  author={Carolina A. Oliva and Jessica Y. Vargas and Nibaldo C. Inestrosa},
  booktitle={Front. Cell. Neurosci.},
During development of the central nervous system the Wnt signaling pathway has been implicated in a wide spectrum of physiological processes, including neuronal connectivity and synapse formation. Wnt proteins and components of the Wnt pathway are expressed in the brain since early development to the adult life, however, little is known about its role in mature synapses. Here, we review evidences indicating that Wnt proteins participate in the remodeling of pre- and post-synaptic regions, thus… CONTINUE READING


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