Wnt9A Induction Linked to Suppression of Human Colorectal Cancer Cell Proliferation

  title={Wnt9A Induction Linked to Suppression of Human Colorectal Cancer Cell Proliferation},
  author={I. Ali and B. Medegan and D. Braun},
  journal={International Journal of Molecular Sciences},
  • I. Ali, B. Medegan, D. Braun
  • Published 2016
  • Biology, Medicine
  • International Journal of Molecular Sciences
  • Most studies of Wnt signaling in malignant tissues have focused on the canonical Wnt pathway (CWP) due to its role in stimulating cellular proliferation. The role of the non-canonical Wnt pathway (NCWP) in tissues with dysregulated Wnt signaling is not fully understood. Understanding NCWP’s role is important since these opposing pathways act in concert to maintain homeostasis in healthy tissues. Our preliminary studies demonstrated that LiCl inhibited proliferation of primary cells derived from… CONTINUE READING
    10 Citations
    Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer
    Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells
    • 14
    • PDF
    Emerging Roles of Wnt Ligands in Human Colorectal Cancer
    • 3
    • PDF
    A tannin compound from Sanguisorba officinalis blocks Wnt/β-catenin signaling pathway and induces apoptosis of colorectal cancer cells
    • 7
    Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies
    • 15
    • PDF
    Small RNA sequencing reveals microRNAs related to neuropathic pain in rats
    • Dawei Dai, J. Wang, +5 authors X. Chen
    • Biology, Medicine
    • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
    • 2019
    • 4
    • PDF


    Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer
    • 60
    Knocking down Wnt9a mRNA levels increases cellular proliferation
    • 19
    Wnt signaling in adult intestinal stem cells and cancer.
    • 270
    • PDF
    Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
    • 169
    • PDF
    Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers
    • 16
    • PDF
    Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.
    • P. Derksen, E. Tjin, +10 authors S. Pals
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2004
    • 300
    • PDF
    Nkd1 Functions as a Passive Antagonist of Wnt Signaling
    • 31
    • PDF
    Wnt signaling and colon carcinogenesis: Beyond APC
    • 164