Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II.

@article{Ciani2011Wnt7aSP,
  title={Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II.},
  author={Lorenza Ciani and Kieran A Boyle and Ellen M. Dickins and Macarena Sahores and Derek Anane and Douglas M Lopes and Alasdair J Gibb and Patricia C. Salinas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 26},
  pages={10732-7}
}
The balance between excitatory and inhibitory synapses is crucial for normal brain function. Wnt proteins stimulate synapse formation by increasing synaptic assembly. However, it is unclear whether Wnt signaling differentially regulates the formation of excitatory and inhibitory synapses. Here, we demonstrate that Wnt7a preferentially stimulates excitatory synapse formation and function. In hippocampal neurons, Wnt7a increases the number of excitatory synapses, whereas inhibitory synapses are… CONTINUE READING
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Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010

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