Wnt5a signaling promotes apical and basolateral polarization of single epithelial cells

@inproceedings{Gon2013Wnt5aSP,
  title={Wnt5a signaling promotes apical and basolateral polarization of single epithelial cells},
  author={Hidetoshi Gon and Katsumi Fumoto and Yonson Ku and Shinji Matsumoto and Akira Kikuchi},
  booktitle={Molecular biology of the cell},
  year={2013}
}
Single epithelial-derived tumor cells have been shown to induce apical and basolateral (AB) polarity by expression of polarization-related proteins. However, physiological cues and molecular mechanisms for AB polarization of single normal epithelial cells are unclear. When intestinal epithelial cells 6 (IEC6 cells) were seeded on basement membrane proteins (Matrigel), single cells formed an F-actin cap on the upper cell surface, where apical markers accumulated, and a basolateral marker was… CONTINUE READING