Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.

  title={Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.},
  author={Hiroyuki Miyoshi and Rieko Ajima and Christine T Luo and T. P. Yamaguchi and Thaddeus S Stappenbeck},
  volume={338 6103},
Reestablishing homeostasis after tissue damage depends on the proper organization of stem cells and their progeny, though the repair mechanisms are unclear. The mammalian intestinal epithelium is well suited to approach this problem, as it is composed of well-delineated units called crypts of Lieberkühn. We found that Wnt5a, a noncanonical Wnt ligand, was required for crypt regeneration after injury in mice. Unlike controls, Wnt5a-deficient mice maintained an expanded population of… CONTINUE READING

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