Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.

@article{Miyoshi2012Wnt5aPT,
  title={Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.},
  author={Hiroyuki Miyoshi and Rieko Ajima and Christine T Luo and T. P. Yamaguchi and Thaddeus S Stappenbeck},
  journal={Science},
  year={2012},
  volume={338 6103},
  pages={108-13}
}
Reestablishing homeostasis after tissue damage depends on the proper organization of stem cells and their progeny, though the repair mechanisms are unclear. The mammalian intestinal epithelium is well suited to approach this problem, as it is composed of well-delineated units called crypts of Lieberkühn. We found that Wnt5a, a noncanonical Wnt ligand, was required for crypt regeneration after injury in mice. Unlike controls, Wnt5a-deficient mice maintained an expanded population of… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
113 Extracted Citations
23 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 113 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 23 references

Hebrok , Wnt 5 a is essential for intestinal elongation in mice

  • T. P. Yamaguchi S. Cervantes, M.
  • Nat . Med .
  • 2011

Repression of the CDK activator Cdc 25 A and cell - cycle arrest by cytokine TGF - β in cells lacking the CDK inhibitor p 15

  • J. Massagué A. Iavarone
  • Dev . Dyn .
  • 2010

Stappenbeck , The stem cell niche

  • S. T.
  • J . Pathol .
  • 2009

A Wnt 5 a pathway underlies outgrowth of multiple structures in the vertebrate embryo

  • A. Bradley, A. P. McMahon, S. Jones
  • Sci . Signal .
  • 2008

A highly efficient recombineeringbased method for generating conditional knockout mutations

  • N. A. Jenkins P. Liu, N. G. Copeland
  • Nature
  • 2007

Igf 2 bp 1 is required for full induction of Ptgs 2 mRNA in colonic mesenchymal stem cells in mice

  • M. R. Drylewicz, H. Miyoshi, T. S. Stappenbeck
  • Nat . Biotechnol .
  • 2007

Similar Papers

Loading similar papers…