Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase Calpha.

@article{Yang2009Wnt5aIR,
  title={Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase Calpha.},
  author={Dong-Hwa Yang and J Yoon and S N Lee and V{\'i}tězslav Bryja and Emma R Andersson and Ernest Arenas and Young-Guen Kwon and Kang-Yell Choi},
  journal={Circulation research},
  year={2009},
  volume={104 3},
  pages={372-9}
}
In this study, we examined the signaling pathways activated by Wnt5a in endothelial differentiation of embryonic stem (ES) cells and the function of Wnt5a during vascular development. We first found that Wnt5a(-/-) mouse embryonic stem (mES) cells exhibited a defect in endothelial differentiation, which was rescued by addition of Wnt5a, suggesting that Wnt5a is required for endothelial differentiation of ES cells. Involvement of both beta-catenin and protein kinase (PK)Calpha pathways in… CONTINUE READING
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