Wnt5a is elevated in heart failure and affects cardiac fibroblast function

  title={Wnt5a is elevated in heart failure and affects cardiac fibroblast function},
  author={Aurelija Abraityte and Leif Erik Vinge and Erik Tandberg Askevold and Tove Lekva and Annika Elisabeth Michelsen and Trine Ranheim and Katrine Alfsnes and Arnt Eltvedt Fiane and Svend Aakhus and Ida Gjervold Lunde and Christen Peder Dahl and P{\aa}l Aukrust and Geir A. Christensen and Lars Gullestad and Arne Yndestad and Thor Ueland},
  journal={Journal of Molecular Medicine},
Wnt signaling is dysregulated in heart failure (HF) and may promote cardiac hypertrophy, fibrosis, and inflammation. Blocking the Wnt ligand Wnt5a prevents HF in animal models. However, the role of Wnt5a in human HF and its functions in cardiac cells remain unclear. Here, we investigated Wnt5a regulation in HF patients and its effects on primary mouse and human cardiac fibroblasts. Serum Wnt5a was elevated in HF patients and associated with hemodynamic, neurohormonal, and clinical measures of… CONTINUE READING


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