Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis.

@article{Ho2012Wnt5aRorDishevelledSC,
  title={Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis.},
  author={Hsin-Yi Henry Ho and Michael W Susman and Jay B. Bikoff and Yun Kyoung Ryu and Andrea M Jonas and Linda I. Hu and Rejji Kuruvilla and Michael E. Greenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 11},
  pages={4044-51}
}
Wnts make up a large family of extracellular signaling molecules that play crucial roles in development and disease. A subset of noncanonical Wnts signal independently of the transcription factor β-catenin by a mechanism that regulates key morphogenetic movements during embryogenesis. The best characterized noncanonical Wnt, Wnt5a, has been suggested to… CONTINUE READING