Wnt5a Is Required for Cardiac Outflow Tract Septation in Mice

@article{Schleiffarth2007Wnt5aIR,
  title={Wnt5a Is Required for Cardiac Outflow Tract Septation in Mice},
  author={Jack Robert Schleiffarth and Anthony D Person and Brad J Martinsen and David Sukovich and Ann R Neumann and Clare V. H. Baker and Jamie L. Lohr and David N. Cornfield and Stephen C. Ekker and Anna Petryk},
  journal={Pediatric Research},
  year={2007},
  volume={61},
  pages={386-391}
}
Lack of septation of the cardiac outflow tract (OFT) results in persistent truncus arteriosus (PTA), a form of congenital heart disease. The outflow myocardium expands through addition of cells originating from the pharyngeal mesoderm referred to as secondary/anterior heart field, whereas cardiac neural crest (CNC) cell–derived mesenchyme condenses to form an aortopulmonary septum. We show for the first time that a mutation in Wnt5a in mice leads to PTA. We provide evidence that Wnt5a is… CONTINUE READING
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