Wnt5a: its signalling, functions and implication in diseases.

  title={Wnt5a: its signalling, functions and implication in diseases.},
  author={Akira Kikuchi and Hideki Yamamoto and Akitsugu Sato and Shinji Matsumoto},
  journal={Acta physiologica},
  volume={204 1},
Wnt5a is a representative ligand that activates the β-catenin-independent pathways. Because the β-catenin-independent pathway includes multiple signalling cascades in addition to the planar cell polarity and Ca(2+) pathway, Wnt5a regulates a variety of cellular functions, such as proliferation, differentiation, migration, adhesion and polarity. Consistent with the multiple functions of Wnt5a signalling, Wnt5a knockout mice show various phenotypes, including an inability to extend the embryonic… CONTINUE READING
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