Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism.

@article{Tanigawa2011Wnt4IN,
  title={Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism.},
  author={Shunsuke Tanigawa and Honghe Wang and Yili Yang and Nirmala Sharma and Nadya I. Tarasova and Rieko Ajima and T. P. Yamaguchi and Luis Gustavo Araujo Rodriguez and Alan O Perantoni},
  journal={Developmental biology},
  year={2011},
  volume={352 1},
  pages={58-69}
}
Wnt4 and β-catenin are both required for nephrogenesis, but studies using TCF-reporter mice suggest that canonical Wnt signaling is not activated in metanephric mesenchyme (MM) during its conversion to the epithelia of the nephron. To better define the role of Wnt signaling, we treated rat metanephric mesenchymal progenitors directly with recombinant Wnt proteins. These studies revealed that Wnt4 protein, which is required for nephron formation, induces tubule formation and differentiation… CONTINUE READING

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