Wnt4 and LAP2alpha as Pacemakers of Thymic Epithelial Senescence

  title={Wnt4 and LAP2alpha as Pacemakers of Thymic Epithelial Senescence},
  author={Kriszti{\'a}n Kvell and Zolt{\'a}n {\'A}. Varecza and Domokos Bartis and Sebastian Hesse and Sonia M Parnell and Graham Anderson and Eric J. Jenkinson and Judit E. Pongr{\'a}cz},
  booktitle={PloS one},
Age-associated thymic involution has considerable physiological impact by inhibiting de novo T-cell selection. This impaired T-cell production leads to weakened immune responses. Yet the molecular mechanisms of thymic stromal adipose involution are not clear. Age-related alterations also occur in the murine thymus providing an excellent model system. In the present work structural and molecular changes of the murine thymic stroma were investigated during aging. We show that thymic epithelial… CONTINUE READING


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