Wnt4 Is a Local Repulsive Cue that Determines Synaptic Target Specificity

@article{Inaki2007Wnt4IA,
  title={Wnt4 Is a Local Repulsive Cue that Determines Synaptic Target Specificity},
  author={Mikiko Inaki and Shingo Yoshikawa and John Bob Thomas and Hiroyuki Aburatani and Akinao Nose},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={1574-1579}
}
How synaptic specificity is molecularly coded in target cells is a long-standing question in neuroscience. Whereas essential roles of several target-derived attractive cues have been shown, less is known about the role of repulsion by nontarget cells. We conducted single-cell microarray analysis of two neighboring muscles (M12 and M13) in Drosophila, which are innervated by distinct motor neurons, by directly isolating them from dissected embryos. We identified a number of potential target cues… CONTINUE READING

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