Wnt3a increases the metastatic potential of non-small cell lung cancer cells in vitro in part via its upregulation of Notch3.

@article{Li2015Wnt3aIT,
  title={Wnt3a increases the metastatic potential of non-small cell lung cancer cells in vitro in part via its upregulation of Notch3.},
  author={Chun-yan Li and Gongru Song and Siyang Zhang and Enhua Wang and Zeshi Cui},
  journal={Oncology reports},
  year={2015},
  volume={33 3},
  pages={1207-14}
}
Metastasis is the leading cause of death in lung cancer. Understanding the mechanisms underlying the process of metastasis is crucial for identifying novel anti-metastatic therapies. Studies indicate that the highly conserved developmental pathways, such as the Wnt and Notch signaling pathways, play important roles in the non-small cell lung cancer (NSCLC) tumorigenesis. However, the roles of both pathways in NSCLC metastasis are unclear. The present study aimed to investigate whether Wnt3a and… CONTINUE READING

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