Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism.

@article{Kobune2007Wnt3RhoAROCKSP,
  title={Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism.},
  author={Masayoshi Kobune and Hiroki Chiba and Junji Kato and Kazunori Kato and Kiminori Nakamura and Yutaka Kawano and Kohichi Takada and Rishu Takimoto and Tetsuji Takayama and Hirofumi Hamada and Yoshiro Niitsu},
  journal={Molecular cancer therapeutics},
  year={2007},
  volume={6 6},
  pages={1774-84}
}
Adhesion of myeloma cells to bone marrow stromal cells is now considered to play a critical role in chemoresistance. However, little is known about the molecular mechanism governing cell adhesion-mediated drug resistance (CAM-DR) of myeloma cells. In this study, we focused our interests on the implication of the Wnt signal in CAM-DR. We first screened the expression of Wnt family in myeloma cell lines and found that Wnt3 was overexpressed in all the myeloma cells examined. KMS-5 and ARH77… CONTINUE READING
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Integrin alpha4beta1 involvement in stromal cell-derived factor1alpha-promoted myeloma cell transendothelial migration and adhesion: Molecular Cancer Therapeutics 1783 Mol Cancer Ther 2007;6(6)

  • M Parmo-Cabanas, RA Bartolome, N Wright, A Hidalgo, AM Drager, J. Teixido
  • June 2007 on April
  • 2007

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