Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin.

Abstract

Current models of canonical Wnt signaling assume that a pathway is active if beta-catenin becomes nuclearly localized and Wnt target genes are transcribed. We show that, in Xenopus, maternal LRP6 is essential in such a pathway, playing a pivotal role in causing expression of the organizer genes siamois and Xnr3, and in establishing the dorsal axis. We… (More)

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