Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts.

@article{Vertino2005Wnt10bDP,
  title={Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts.},
  author={Anthony M Vertino and Jane M Taylor-Jones and Kenneth A. Longo and Edward D. Bearden and Timothy F. Lane and R E Mcgehee and Ormond A Macdougald and Charlotte A. Peterson},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 4},
  pages={
          2039-48
        }
}
Adult myoblasts retain plasticity in developmental potential and can be induced to undergo myogenic, adipogenic, or osteoblastogenic differentiation in vitro. In this report, we show that the balance between myogenic and adipogenic potential in myoblasts is controlled by Wnt signaling. Furthermore, this balance is altered during aging such that aspects of both differentiation programs are coexpressed in myoblasts due to decreased Wnt10b abundance. Mimicking Wnt signaling in aged myoblasts… CONTINUE READING

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