Wnt1 overexpression promotes tumour progression in non-small cell lung cancer.

@article{Huang2008Wnt1OP,
  title={Wnt1 overexpression promotes tumour progression in non-small cell lung cancer.},
  author={Cheng-long Huang and Dage Liu and Shinya Ishikawa and Takashi Nakashima and Nariyasu Nakashima and Hiroyasu Yokomise and Kyuichi Kadota and Masaki Ueno},
  journal={European journal of cancer},
  year={2008},
  volume={44 17},
  pages={2680-8}
}
BACKGROUND The Wnt gene family is involved in embryogenesis and tumourigenesis. We investigated the clinical significance of Wnt1 expression in non-small cell lung cancer (NSCLC). METHOD We studied 216 NSCLC patients. Immunohistochemistry was performed to investigate the Wnt1 expression in relation to the expression of beta-catenin and Wnt-targets, including c-Myc, Cyclin D1, VEGF-A and MMP-7. The Ki-67 proliferation index and the intratumoural microvessel density (IMD) were also evaluated… CONTINUE READING