Wnt signalling regulates myogenic differentiation in the developing avian wing.

@article{Anakwe2003WntSR,
  title={Wnt signalling regulates myogenic differentiation in the developing avian wing.},
  author={Kelly Anakwe and Lesley G. Robson and Julia Hadley and Paul Buxton and Vicki L. Church and Steve Allen and Christine Hartmann and Brian D Harfe and Tsutomu Nohno and Anthony M. C. Brown and Darrell J. R. Evans and Philippa H Francis-West},
  journal={Development},
  year={2003},
  volume={130 15},
  pages={3503-14}
}
The limb musculature arises by delamination of premyogenic cells from the lateral dermomyotome. Initially the cells express Pax3 but, upon entering the limb bud, they switch on the expression of MyoD and Myf5 and undergo terminal differentiation into slow or fast fibres, which have distinct contractile properties that determine how a muscle will function. In the chick, the premyogenic cells express the Wnt antagonist Sfrp2, which is downregulated as the cells differentiate, suggesting that Wnts… CONTINUE READING
67 Citations
74 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 67 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 74 references

Similar Papers

Loading similar papers…