Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

@inproceedings{Carotenuto2017WntSM,
  title={Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers},
  author={Pietro Carotenuto and Matteo Fassan and Rosantony Pandolfo and Andrea Lampis and Caterina Vicentini and Luciano Cascione and Viola Paulus-Hock and Luke Boulter and Rachel Victoria Guest and Luca Quagliata and Jens C Hahne and Rachel A. Ridgway and Tam Jamieson and Dimitris Athineos and Angelo Veronese and Rosa Visone and Claudio Murgia and Giulia Maria Ferrari and Vincenza Guzzardo and Thomas Ronald Jeffry Evans and Martin MacLeod and Gui Ji Feng and Trevor C Dale and Massimo Negrini and Stuart J Forbes and Luigi Maria Terracciano and Aldo Scarpa and Tushar Patel and Nicola Valeri and Paul Workman and Owen James Sansom and Chiara Braconi},
  booktitle={Gut},
  year={2017}
}
OBJECTIVE Transcribed-ultraconserved regions (T-UCR) are long non-coding RNAs which are conserved across species and are involved in carcinogenesis. We studied T-UCRs downstream of the Wnt/β-catenin pathway in liver cancer. DESIGN Hypomorphic Apc mice (Apcfl/fl) and thiocetamide (TAA)-treated rats developed Wnt/β-catenin dependent hepatocarcinoma (HCC) and cholangiocarcinoma (CCA), respectively. T-UCR expression was assessed by microarray, real-time PCR and in situ hybridisation. RESULTS… CONTINUE READING
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