Wnt signalling is a bi-directional vulnerability of cancer cells

  title={Wnt signalling is a bi-directional vulnerability of cancer cells},
  author={David J. Duffy and Aleksandar Krstic and Thomas Schwarzl and Melinda Halasz and Kristiina Iljin and Dirk Fey and Bridget Haley and Jenny Whilde and Saija Haapa-Paananen and Vidal Fey and Matthias Hermann Fischer and Frank Westermann and Kai-Oliver Henrich and Steffen Bannert and Desmond G. Higgins and Walter Kolch},
Wnt signalling is involved in the formation, metastasis and relapse of a wide array of cancers. However, there is ongoing debate as to whether activation or inhibition of the pathway holds the most promise as a therapeutic treatment for cancer, with conflicting evidence from a variety of tumour types. We show that Wnt/β-catenin signalling is a bi-directional vulnerability of neuroblastoma, malignant melanoma and colorectal cancer, with hyper-activation or repression of the pathway both… CONTINUE READING
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