Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours

@article{Veeck2008WntSI,
  title={Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours},
  author={Juergen Veeck and Nuran Bektas and Arndt Hartmann and Glen Kristiansen and Uwe Heindrichs and Ruth Knuechel and Edgar Dahl},
  journal={Breast Cancer Research : BCR},
  year={2008},
  volume={10},
  pages={R82 - R82}
}
Expression of the putative Wnt signalling inhibitor Dickkopf-3 (DKK3) is frequently lost in human cancer tissues because of aberrant 5'-cytosine methylation within the DKK3 gene promoter. Since other Wnt signalling inhibitors have been reported to be targets of epigenetic inactivation in human breast cancer, we questioned if DKK3 expression is also… CONTINUE READING